ML-k’sNN: Label Dependent k Values for Multi-Label k-Nearest Neighbor Rule

Multi-label classification as a data mining task has recently attracted increasing interest from researchers. Many current data mining applications address problems with instances that belong to more than one category. These problems require the development of new, efficient methods. Multi-label k-nearest neighbors rule, ML-kNN, is among the best-performing methods for multi-label problems. Current methods use a unique k value for all labels, as in the single-label method. However, the distributions of the labels are frequently very different. In such scenarios, a unique k value for the labels might be suboptimal. In this paper, we propose a novel approach in which each label is predicted with a different value of k. Obtaining the best k for each label is stated as an optimization problem. Three different algorithms are proposed for this task, depending on which multi-label metric is the target of our optimization process. In a large set of 40 real-world multi-label problems, our approach improves the results of two different tested ML-kNN implementations

Graph-Based Feature Selection Approach for Molecular Activity Prediction

In the construction of QSAR models for the prediction of molecular activity, feature selection is a common task aimed at improving the results and understanding of the problem. The selection of features allows elimination of irrelevant and redundant features, reduces the effect of dimensionality problems, and improves the generalization and interpretability of the models. In many feature selection applications, such as those based on ensembles of feature selectors, it is necessary to combine different selection processes. In this work, we evaluate the application of a new feature selection approach to the prediction of molecular activity, based on the construction of an undirected graph to combine base feature selectors. The experimental results demonstrate the efficiency of the graph-based method in terms of the classification performance, reduction, and redundancy compared to the standard voting method. The graph-based method can be extended to different feature selection algorithms and applied to other cheminformatics problems

CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110

BACKGROUND: In the search for novel antibody-drug conjugates (ADCs) with therapeutic potential, it is imperative to identify novel targets to direct the antibody moiety. CD13 seems an attractive ADC target as it shows a differential pattern of expression in a variety of tumors and cell lines and it is internalized upon engagement with a suitable monoclonal antibody. PM050489 is a marine cytotoxic compound tightly binding tubulin and impairing microtubule dynamics which is currently undergoing clinical trials for solid tumors. METHODS: Anti-CD13 monoclonal antibody (mAb) TEA1/8 has been used to prepare a novel ADC, MI130110, by conjugation to the marine compound PM050489. In vitro and in vivo experiments have been carried out to demonstrate the activity and specificity of MI130110. RESULTS: CD13 is readily internalized upon TEA1/8 mAb binding, and the conjugation with PM050489 did not have any effect on the binding or the internalization of the antibody. MI130110 showed remarkable activity and selectivity in vitro on CD13-expressing tumor cells causing the same effects than those described for PM050489, including cell cycle arrest at G2, mitosis with disarrayed and often multipolar spindles consistent with an arrest at metaphase, and induction of cell death. In contrast, none of these toxic effects were observed in CD13-null cell lines incubated with MI130110. Furthermore, in vivo studies showed that MI130110 exhibited excellent antitumor activity in a CD13-positive fibrosarcoma xenograft murine model, with total remissions in a significant number of the treated animals. Mitotic catastrophes, typical of the payload mechanism of action, were also observed in the tumor cells isolated from mice treated with MI130110. In contrast, MI130110 failed to show any activity in a xenograft mouse model of myeloma cells not expressing CD13, thereby corroborating the selectivity of the ADC to its target and its stability in circulation. CONCLUSION: Our results show that MI130110 ADC combines the antitumor potential of the PM050489 payload with the selectivity of the TEA1/8 monoclonal anti-CD13 antibody and confirm the correct intracellular processing of the ADC. These results demonstrate the suitability of CD13 as a novel ADC target and the effectiveness of MI130110 as a promising antitumor therapeutic agent.This work was partially supported by grant IPT-2012-0198-090000 (“MARINMAB” project) from Ministerio de Economía y Competitividad (MINECO) and European Regional Development’s funds (ERDF) and by CSIC grant 2019AEP146.S

Leadership and quality in Higher Education

En la Universidad del Siglo XXI, la función de liderazgo está en la base de los procesos de surgimiento, mantenimiento e institucionalización de una nueva cultura de la calidad (Fernández Cruz, 2015). En este contexto, las universidades han creado unas Unidades de Calidad como responsables de los procesos de acreditación, seguimiento y renovación de títulos que deben actuar como verdaderos impulsores de unas acciones de mejora para las que resulta indispensable la puesta en marcha de procesos de evaluación y seguimiento que exigen el ejercicio de un liderazgo que fomente una cultura de calidad que impregne el quehacer diario de la institución. Los nuevos Títulos de Grado establecidos dentro del Espacio Europeo de Educación Superior demandan una serie de actuaciones que deben ser ejecutadas por los llamados Coordinadores de Grado como responsables de la coordinación de los equipos docentes. Además de lo anterior, el proceso de internacionalización que conlleva el Espacio Europeo de Educación Superior supone el desarrollo de estrategias de liderazgo a nivel interno, que se han traducido hacia el exterior en un fuerte liderazgo institucional (Cleveland-Innes, 2012; Juárez- Casalengua, 2015), y en un impulso y liderazgo político e institucional de la UE.In the 21st century university, the leadership function is at the base of the processes of emergence, maintenance and institutionalization of a new culture of quality (Fernández Cruz, 2015). In this context, the universities have created Quality Units to facilitate the process of accreditation, monitoring and renewal official degrees. This units must act as real drivers of improvement for which it is essential implement assessment and monitoring procedures that require a leadership that foster a culture quality in the daily activities of the institution. The new official degrees established under European Higher Education Area demand a series of actions that must be carried out by the so-called Degree Coordinators as responsible for the coordination of the teaching teams. In addition to the above, the internationalization that entails the European Higher Education Area implies the development of internal leadership strategies that have been turned into strong institutional leadership (Cleveland-Innes, 2012; Juárez-Casalengua, 2015), and in an impetus and political and institutional leadership of the EU. On the other hand, as most of the research on leadership has traditionally focused on managerial positions, we have wanted to approach from an alternative perspective the leadership function exercised by university students through the different representation positions they perform

Proceso de renovación de la acreditación del Grado en Geología de la Universidad de Alicante

Desde que se iniciaron los estudios de Grado en Geología en la Universidad de Alicante (curso académico 2010-11), todos los grupos de interés implicados en su implantación y funcionamiento (estudiantes, personal académico, personal de apoyo a la docencia, gestores, egresados, empleadores,…) han llevado a cabo las tareas de seguimiento, evaluación y mejora relacionadas con el cumplimiento de los estándares y directrices para la garantía de calidad del programa formativo en el Espacio Europeo de Educación Superior (EEES). Entre ellos se incluyen los dirigidos a la renovación de la acreditación inicial del título siguiendo las directrices de Agència Valenciana d’Avaluació i Prospectiva (AVAP), como son la elaboración de los informes anuales de seguimiento interno y del Informe de Autoevaluación del Título (IAT), basándose en las evidencias obtenidas por el Sistema de Garantía Interna de la Calidad (SGIC), con especial referencia a los indicadores cuantitativos obtenidos y a la preparación de la visita del Comité de Evaluación Externa (CEE) de la AVAP durante el presente curso académico (2015-16)

Entrevistas a artistas y formatos de interacción. Red para el intercambio de conocimientos y experiencias entre artistas y conservadores-restauradores

Este proyecto ha tenido como objetivo la creación de una red interdisciplinar, internivelar, interdepartamental e interfacultativa de profesores, estudiantes y alumni de las áreas de Bellas Artes, Conservación-Restauración y Diseño de la Universidad Complutense de Madrid y de la Universidad de La Laguna. El presente proyecto surge de la necesidad constatada durante el contexto del COVID-19 de proporcionar nuevas herramientas a los estudiantes que les permitan desarrollar las competencias que sus titulaciones establecen y de fortalecer el tejido de interacciones transdisciplinares dentro de la Facultad de Bellas Artes. A través de una convocataoria pública a artistas y de una reflexión en torno a la metodología de entrevista al artista en conservación-restauración de arte contemporáneo, se han desarrollado dinámicas interdisciplinares y estrategias de enseñanza-aprendizaje horizontales entre artistas, profesores y estudiantes de distintos niveles (grado, postgrado, doctorado) como fórmula para amplificar la generación de conocimiento en la universidad. El proyecto ha abarcado la dirección de TFGs, el desarrollo de una investigación en torno a nuevos formatos de interacción entre conservadores-restauradores y artistas, y el desarrollo de dos seminarios públicos. Esta memoria recoge los objetivos propuestos y evalúa los alcanzados en base a una serie de indicadores, describe la metodología utilizada en el proyecto, analiza las características del equipo de trabajo y expone las actividades desarrolladas durante el curso 2020-2021. Los Anexos incluyen documentación sobre las actividades desarrolladas e imágenes sobre los procesos de investigación

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Diverse Large HIV-1 Non-subtype B Clusters Are Spreading Among Men Who Have Sex With Men in Spain

In Western Europe, the HIV-1 epidemic among men who have sex with men (MSM) is dominated by subtype B. However, recently, other genetic forms have been reported to circulate in this population, as evidenced by their grouping in clusters predominantly comprising European individuals. Here we describe four large HIV-1 non-subtype B clusters spreading among MSM in Spain. Samples were collected in 9 regions. A pol fragment was amplified from plasma RNA or blood-extracted DNA. Phylogenetic analyses were performed via maximum likelihood, including database sequences of the same genetic forms as the identified clusters. Times and locations of the most recent common ancestors (MRCA) of clusters were estimated with a Bayesian method. Five large non-subtype B clusters associated with MSM were identified. The largest one, of F1 subtype, was reported previously. The other four were of CRF02_AG (CRF02_1; n = 115) and subtypes A1 (A1_1; n = 66), F1 (F1_3; n = 36), and C (C_7; n = 17). Most individuals belonging to them had been diagnosed of HIV-1 infection in the last 10 years. Each cluster comprised viruses from 3 to 8 Spanish regions and also comprised or was related to viruses from other countries: CRF02_1 comprised a Japanese subcluster and viruses from 8 other countries from Western Europe, Asia, and South America; A1_1 comprised viruses from Portugal, United Kingom, and United States, and was related to the A1 strain circulating in Greece, Albania and Cyprus; F1_3 was related to viruses from Romania; and C_7 comprised viruses from Portugal and was related to a virus from Mozambique. A subcluster within CRF02_1 was associated with heterosexual transmission. Near full-length genomes of each cluster were of uniform genetic form. Times of MRCAs of CRF02_1, A1_1, F1_3, and C_7 were estimated around 1986, 1989, 2013, and 1983, respectively. MRCA locations for CRF02_1 and A1_1 were uncertain (however initial expansions in Spain in Madrid and Vigo, respectively, were estimated) and were most probable in Bilbao, Spain, for F1_3 and Portugal for C_7. These results show that the HIV-1 epidemic among MSM in Spain is becoming increasingly diverse through the expansion of diverse non-subtype B clusters, comprising or related to viruses circulating in other countries

Ciencia Odontológica 2.0

Libro que muestra avances de la Investigación Odontológica en MéxicoEs para los integrantes de la Red de Investigación en Estomatología (RIE) una enorme alegría presentar el segundo de una serie de 6 libros sobre casos clínicos, revisiones de la literatura e investigaciones. La RIE está integrada por cuerpos académicos de la UAEH, UAEM, UAC y UdeG

El centro como espacio de desarrollo personal y comunitario

Sigue la línea del curso anterior como respuesta a las necesidades, carencias y dificultades que se encuentra el alumnado en la ESO. Trabaja cuatro aspectos complementarios: programa de entrenamiento cognitivo en las operaciones básicas; tutoría centrada en los cambios fisiológicos, afectivos, cognitivos y de personalidad de los adolescentes; conductas académicas y convivenciales; y técnicas de relajación y concentración mental. Diseña introducciones escritas por el coordinador para cada una de las operaciones y 24 actividades elaboradas por los profesores. Se evalúa la correcta aplicación de las estrategias y la calidad de los productos cognitivos elaborados por medio de la observación directa, diálogo con alumnos y realización escrita de las actividades por parte del alumnado.Madrid (Comunidad Autónoma). Consejería de Educación y CulturaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES